The use of e-cigarettes—particularly among youth and young adults—has become a growing concern in Ontario. Local health units have a strong interest in implementing evidence-based interventions to counter the uptake of e-cigarette use. For this report, OTRU conducted a review of vaping interventions that could be implemented at a local level. With a focus on prevention, our search found several promising practices but little evaluative evidence on their effectiveness. Most interventions observed were public education and school-based efforts. Other interventions included community-based interventions, health-care provider interventions, aerosol-free policies, age restrictions and advertising and promotion restrictions. A vaping path logic model is presented to help organize possible interventions and expected outcomes.